Captain Stottlemeyer (Ted Levine) is Adrian Monk's former partner and boss, the longtime friend who was ultimately forced to let Monk go from the San Francisco Police Department when his obsessive-compulsive disorder began to dangerously interfere with his work.

Though often annoyed and baffled 由 his friend's behavior, Stottlemeyer recognizes Monk's brilliance and frequently calls upon his old partner to provide unique insight into cases that have San Francisco's finest stumped. And although it can drive Stottlemeyer crazy to know that he'll never be quite as brilliant a detective as Monk, the divorced father of two remains a loyal friend.

Natalie Teeger (Traylor Howard) is Adrian Monk's devoted personal assistant, a strong, self-reliant single mom whose tough 爱情 proves to be exactly what Monk needs. Though often frustrated and confused 由 her boss’s peculiar behavior, Natalie remains a caring but firm assistant and friend, pushing Monk to overcome his debilitating fears and compulsions.

The fiercely independent former bartender (and member of the wealthy 长椅, 达文波特 family) shares a special bond with Monk, having also tragically 迷失 her spouse, and she and her teenage daughter, Julie, have become a surrogate family for Monk. With her no-nonsense attitude, knack for investigation, and ability to challenge Monk, Natalie has become much 更多 than just a sidekick to the brilliant detective.