Definitely has to be Hughes' passing from FMA in both FMA and FMA Brotherhood was awfully sad it was awful to see such a great man pass in the fashion he did.
Grave of the Fireflies: *Main character dies immediately. Flashback to his last days on earth. *Bomb dropped, house destroyed. *Kids find mother in a hospital wrapped head to toe in bandages. She dies. *Relatives treat kids like crap. Woman nags little boy to 加入 military. *Children become homeless, live in a cave. *Sister (a toddler) dies of malnutrition. *Boy learns that his father's plane was shot down.
Barefoot Gen: *Bomb drops on town. Children, babies, & a dog are burnt up, liquefied, & showered with shards of glass. *Main character loses his home. *Caved-in roof crushes dads skull. *Mother watches helplessly as her children burn to death. Stress causes premature birth of child. *Boy starts to 显示 the same symptoms as a man he watched die of radiation poisoning. 安全 bet he has cancer now. *Boy & adopted brother get jobs to buy 牛奶 for the baby because the mother has no 食物 to make milk. The baby dies of starvation.
There is absolutely no scene (other than the Code Geass R2 ending) that is 更多 tear-jerking than this ending scene to 天使 Beats. (Though I think some of the feeling was 迷失 with the translation and terrible dub.)
In an 日本动漫 called Tokyo magnitude 8.0 its one of the saddest moments of 日本动漫 ive ever seen, i cried through 2 whole episodes 40 min and then i cried 更多 later 😢