In order to prevent all of humankind from being turned into mutants, the X-Men, the Brotherhood, S.H.I.E.L.D., The Acolytes, Angel, Spyke, Havok, and the New Mutants all 加入 forces to save humanity from the ambitions of Apocalypse.
Despite rescuing Professor X, the bigotry towards mutants still exists as our 超能英雄 return to Bayville High, scorned and verbally abused 由 their human classmates, including their mutant-hating Principal Edward Kelly.