Well it really depends on which show/movie your looking at , Im Twilight its because the 吸血鬼 kill people and the 狼 are the protectors but in vampire diares its because there both uncontrollable things so really it depends but form all the fiction things i have read over the years its 更多 of just a mortal enemy type thing that there naturaly born to kill each other
The 狼人 came into existence as protectors of their tribe. Then a pair of 吸血鬼 attacked the tribe and another neighbouring tribe. Those 吸血鬼 were the most dangerous enemies the 狼 had ever fought. They've been natural enemies ever since.