Michael Scofield, a structural engineer, attempts to rob a bank in order to get incarcerated at 狐狸 River State Penitentiary, where his brother 林肯 Burrows, accused of murdering the Vice President's brother, is scheduled to be executed.
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Michael seeks the help of his fellow prison inhabitants to execute his escape plans. Racial tensions escalate inside the prison.
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When Michael reveals his escape plan to Sucre, Sucre chooses to be no part of it, and requests a cell transfer. Michael gets a new cellmate called Haywire.
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Veronica uncovers new information regarding Lincoln's case and decides she wants to work on the case full-time. When no one wants to help her, Nick Savrinn (an attorney) offers his assistance and the two of them visit Lincoln.
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Kellerman and Hale blackmail Warden Pope. Michael finds out he might get out earlier than anticipated. Veronica becomes uncertain of her allies.
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Michael creates a lockdown 由 sabotaging the air conditioning in order to execute his breakout plan properly, and unintentionally causes a riot that gets Sara into huge trouble.
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While the riot intensifies, Abruzzi and Sucre 加入 forces. Michael must decide whether 或者 not to save the life of Dr. Tancredi.
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Michael finds out a storeroom fundamental to his escape plans has been converted into a break room. Veronica and Nick are being threatened, so they go to Nick's place which is off the radar of the Secret Service.
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Abruzzi's demotion in the prison hierachy puts the entire escape plan at risk. Michael finds himself in the uneviable position of trying to protect T-Bag's new "fish".
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Abruzzi struggles to get his crew back to PI. He tries to convince Michael to reveal Fibonacci's whereabouts to Falzone.
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