During Pain's invasion of Konoha he confronts several ninja inquiring about the location of the Nine-Tailed Demon Fox, eventually leading his 搜索 to Iruka. Iruka refuses to reveal anything and is about to be killed. 卡卡西 intervenes, telling Iruka to leave with the injured ninja. 卡卡西 then confronts Pain's Deva Path, but despite his methodical tactics, Pain proves too powerful for him to land a single blow due to his body's special abilities. He quickly summarizes the bodies and their strengths and weaknesses. 卡卡西 is later joined 由 Choji and Choza Akimichi. After a long battle, Choza is defeated and 卡卡西 is left with barely any chakra. 卡卡西 orders Choji to go and tell Tsunade about Pain's powers, and activates his Mangekyo Sharingan to save Choji from a fatal blow, knowing fully well that using it in his current state would very likely lead to his death. As he feels himself losing consciousness, he begins thinking about his dearest 老友记 Obito and Rin. 卡卡西 then finds himself in an area surrounded 由 darkness approaching a campfire with his father waiting for him, and asked him about himself. Meanwhile, 卡卡西 and the Asura Path are both rendered incapacitated. Later, when Choji arrived at Tsunade's location, she ordered Choji to get 卡卡西 and his father to a hospital, making no 评论 when Choji asked if 卡卡西 was okay, hinting that he is in a critical state if not already dead.