What is the saddest scene in an anime/manga?

In FMA when Maes Hughes died.

ok , i understand that light needed to kill l so he could become " GOD " 或者 sth , ugh , but its very mean to makeTHAT " creepy - twisted " SMILE when l died , i just wanna slap him ><

When Yoite died~
I was so~ extremely, sad~
i cried for hours.....and even now...just thinking about it...makes..me...saaad~ D':
I recently bought vol. 9 and 10 of Nabari no ou. i didnt actually think about which volumes i bought at that time, i saw Yoite at the front cover and.... yea~
so when i got back at the hotel, i decided; Lets read Nabari no ou, here, where its lots of ppl! ( i was in the lobby :P) then, i red vol. 9 and thought...hmm.....something doesnt feel right~
then...i read vol. 10.....and.. Yoite... died.....And i sat there, with lots of ppl around me, and was like; DONT CRY~ DONT CRY~ FOR GODS SAKE! DONT CRY~ (It didnt work though) so i turned away from all those ppl and cried...quietly.......( i hope no one noticed.. :P )

and btw~ that picture has nothing to do with his death :)

Ushio's death ! :(
From Clannad After Story

Nagisa's death

The ending of Cowboy Bebop (which I saw on Toonami last night).

I'm not going to spoil it for anyone, but I will say one thing: it managed to make me cry. And it takes a lot for an 日本动漫 to make me cry.

When Kanade Tachibana graduates and leaves Otonashi Yuzuru behind... I cried for a month
(.>,<.)

kusaka and akizuki's death i cried for about an 小时 after i watched/read it

This scene. This freaking scene. No matter how many times I watch it, I can't get through it without crying.

The Ending to Bokura Ga Ita , it left me depressed..T.T
and Misty's Good bye song:
link

Code Geass R2 ending

I could could name so many Lust-sans,Envy-kun's,Alexander and Nina's (also being turned into a chimera 由 her own father), Lieutenant Colonel Hughes' passing from FMA/FMA Brotherhood,Mr.Kaiba trying to Save Mokuba but ended up being turned to stone 由 Noa also when Mr.Kaiba tried to duel Peggy but 迷失 his soul in attempt to get Mokuba's back,also hearing Peggy's past with his lover Cynthia in Yu-Gi-Oh,mostly ever part of AnoHana was sad for me,L-sama's passing in Death Note was very sad,Ushi-chan and Nagi-san's passing in Clannad + After Story was sad I felt really bad for Tomoya-kun..yes my 列表 can go on I cry at almost everything I find to be sad.

Ichigo and Rukia's farewell...

Dammit! I cried and my 心 was broken in a hundred pieces...Just 由 staring at their faces, their words, their feelings...
Studio Pierrot made a great work with the 音乐 and the 动画片 was flawless. Never ever seen anything so touching and heartbreaking.